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Martinez explained the indication for the therapy to the patient and his wife by educating them about ST elevations and the need to treat symptoms quickly in order to provide blood supply to the heart muscle.

Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.

BARI results have indicated that CABG produces better long-term survival rates than PCI (pre-stent).

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CD36 can translocate between intracellular endosomes and the sarcolemmal membrane, which appears to be important in the regulatory control of fatty acid uptake ().

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As we discussed in section ii K, the proportion of glycolytic pyruvate being oxidized, and the subsequent intracellular acidosis that follows, may actually be more important with regard to functional outcome, rather than simply increasing glycolytic ATP production.

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Results of the proposed study will provide initial dosing estimates for a follow-up, multiple-dose pharmacokinetic study in this population.

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Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (INa).

Therefore, before using ranolazine, report all medications you are currently using to your doctor or pharmacist.

Abstract: Mortality rates attributable to coronary heart disease have declined in recent years, possibly related to changes in clinical presentation patterns and use of proven secondary prevention strategies.

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The more recent, etomoxir for the recovery of glucose oxidation (ERGO) study had to be stopped early as several patients with NYHA class II-class III heart failure in the treatment group were found to have elevated liver transaminase enzyme levels ().

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Further, ranolazine reduced the incidence of death, myocardial infarction, or target-vessel revascularization at 30 days after the procedure (ranolazine 9% vs.

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Psychotherapy, behavioral therapy, and serotonin reuptake inhibitors (SSRIs), which are safe to administer after an acute coronary syndrome, have been shown to reduce mortality and improve recovery from myocardial infarctions (Humphreys, 2011).

Before using pimozide, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

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In the reciprocal, dronedarone may also cause prolongation of the QT interval and as such, by administering dronedarone with ranolazine, it is contemplated a reduction of the QT interval will be seen.

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It is possible that sicker patients with PAH, who have more advanced RV dysfunction, would demonstrate even greater benefit from ranolazine than demonstrated in our study; however, additional studies are needed to fully explore the role of ranolazine in high-risk patients with PAH.

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The findings of the OAT study, however, should not be interpreted as applying to all patients experiencing ST-elevation MI, but just to those with a late occluded artery and no- or minimal angina.

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Probabilities of obstructive coronary disease shown reflect the estimates for patients aged 35, 45, 55, 65, 75 and 85 years.

Cardiac overexpression of FACS results in lipid accumulation, cardiac hypertrophy, gradual development of LV dysfunction, and premature death ().

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Rousseau et al compared immediate-release ranolazine 400 mg TID with atenolol 100 mg QD or placebo in a 1-week double-blind, 3-period, placebo-controlled, crossover study in 158 patients with chronic angina.

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Detailed whole-cell patch-clamp and extracellular multielectrode recordings revealed significant prolongation of the action-potential duration in LQTS human iPSC-derived cardiomyocytes (the characteristic LQTS phenotype) when compared to healthy control cells.

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Increased fatty acid uptake observed in obesity and diabetes may also be dependent on greater expression and localization of sarcolemmal fatty acid transporters.

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The Guidelines do not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with that patient and, where appropriate and necessary, the patient's guardian or carer.

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The relative indications for PCI and CABG in SCAD patients have been clearly defined by the recent recommendations.

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