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Although H pylori is found to be present in 43% to 56% of patients with peptic ulcer bleeding, upper gastrointestinal bleeding can come from additional sources, including tumors, so testing with direct visualization is the best approach.

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Drugs of choice are macrolides (usually azithromycin) or fluoroquinolones with or without rifampin.

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Erythromycin 250mg four times daily for 14 days is the treatment of choice and other antibacterials include tetracycline and chloramphenicol; however, the use of chloramphenicol is limited by bone marrow suppression potentially leading to neutropenia, agranulocytosis and aplastic anaemia.

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