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Hi everyone. I was diagnosed with diabetes type 2 about seven years ago. During this time I have changed many medications to control my blood sugar levels. For the last two years I have been on Metformin twice a day. But that was not the best solution for me as I had frequent problems with my stomach like diarrhea and colitis. So I asked my doctor to select another medication for me and soon he prescribed me with Gliclazide once a day. That was about three month ago and since that time I really felt no more pain in my stomach and there were no more diarrhea attacks. However at first I felt considerably fatigued during the day. This strange feeling soon disappeared and now everything seems to be perfect. About three weeks ago I had another test and the results were much better than with Metformin. I am actually happy with Gliclazide and even if the fatigue wouldn't leave I would still prefer it to other drugs as it causes considerably less side effects and produces better results at the same time. Besides it is easier to take the medication - once a day you have fewer chances to forget about the next dosage.
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I am 43 years of age and I have diabetes type 2 since I was a teenager. I have been on Gliclazide for at least three years now. I must say that I am more than just pleased with the way this medication copes with my diabetes. I have never found any problem with Gliclazide. However to be honest I have to say that before Gliclazide there were also effective medications that helped me control my blood sugar levels. There was just one problem with those meds I liked - they all caused me to gain weight. And I don't want to look like a donut. I am an attractive man and I enjoy success with women. I'm fed up with having to deal with the disease till the end of my life so I wouldn't tolerate any side effects, especially affecting my appearance. With Gliclazide I have no concerns about my weight - it keeps at the point I like without any additional efforts. And it keeps me alive, what is the most important thing of course!
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This is a serious problem, because fasting blood glucose and hemoglobin A1c are almost always the only tests doctors run to screen for diabetes and blood sugar issues.
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Reducing Progression of Diabetic Nephropathy by Antihyperglycemic Treatment.
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Metformin (Glucophage, Glumetza) is an oral diabetes medication that helps control blood sugar.
Previous studies suggest that diabetes atherosclerosis has similarities with diabetic microangiopathy and may partly develop from the metabolic cascade activated via hyperglycemia-induced polyol pathway hyperactivity.
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The idealized diagram shows the fluctuation of (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day containing three meals.
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If the CI for a particular effect estimate was wholly within 1 of the zones then the outcome would be graded as having no serious imprecision; if the CI spanned 2 of the zones, the outcome would be graded as having 'serious imprecision'; and if the CI spanned all 3 zones, then the outcome would be graded as having 'very serious imprecision'.
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Women with a history of diabetes before pregnancy or with preexisting hypertension, renal disease, or autoimmune disorders were excluded.
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Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA: Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.
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If left undiagnosed or untreated, sugar will build up in your bloodstream and starve your cells of energy and potentially lead to blindness, kidney failure, and possible heart attack.
An elevated level of plasma homocysteine has long been suspected as a metabolic risk factor for the development of atherosclerotic vascular diseases in diabetes.
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However, the clinical preparations prepared from such insulins differ from endogenous human insulin in several important respects; an example is the absence of which has in recent years been shown to have systemic effects itself.
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The combination of a substantial difference in HOMA-%S and a small difference in HOMA-%B from week 52 to 104 may explain the difference between the two treatments in glycemic control over time.
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The issues discussed above concerning the management of type 1 and type 2 diabetes also apply to this group, with the exception that more frequent monitoring and insulin dose adjustment is necessary.
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