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Simvastatin but not ezetimibe reduces sympathetic activity despite similar reductions in cholesterol levels.

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Assess for conditions where treatment is contraindicated and risk factors for skeletal muscle toxicity.

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In one three-year study that looked at preventing a first heart attack, 5 percent of people who took a placebo had a heart attack compared to 3 percent of those who took a statin.

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Of the 2396 patients who received Zetia in clinical studies, 669 (28%) were 65 and older, and 111 (5%) were 75 and older.

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