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Effect of intial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes.
Given that this arm of the study depends on comparison of two open treatment regimens, albeit randomised, the progressive awareness of the importance of 'tight glucose control' across the world will make it harder to achieve this separation.
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With accumulating data establishing the glycemic control and other benefits of the incretin agents, it is now possible to envision how these new drugs might eventually be incorporated into routine care of T2DM.
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Marked hyperglycemia requires temporary adjustment of the treatment program and, if accompanied by ketosis, vomiting, or alteration in level of consciousness, immediate interaction with the diabetes care team.
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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
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My question is this: is there any negative repercussion that may occur if I go on a low-carb way of eating again, now that I have these two underlying conditions?
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Andersson C, Olesen JB, Hansen PR, Weeke P, Norgaard ML, Jorgensen CH, et al.
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Because this study was small and because children with type 1 diabetes already need to follow a careful diet, it is difficult to advocate for not confirming the diagnosis by biopsy before recommending a lifelong gluten-free diet, especially in asymptomatic children.
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What you need to ask is what is the “mechanism” in this diet that causes that?
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Evidence-based diabetes care could be highly cost effective.
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Tomato juice, potatoes, legumes and other sources of carbs are all terrible advice.
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Treatment-associated nausea declined with time for both study arms but persisted longer in patients treated with exenatide.
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Primary endpoint was a 25% greater reduction in urinary protein excretion (detected using 24-hour urine determinations) in the combination group as compared to either trandolapril or verapamil alone.
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While actual health outcomes were not evaluated in this study, overall it provides strong support for the results of most prospective epidemiologic studies that show lower rates of cardiovascular and other diseases among light-to-moderate drinkers than among abstainers or heavy drinkers.
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In any case, the striking reduction in risk shown in the study from the Med-Diet provide further evidence of the effectiveness of such a diet in reducing cardiovascular disease.
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The more years you spend with high blood sugars, the more likely you are to develop impotence (both male and female), and gastroparesis, which refers to the condition where your food no longer moves through your body in a normal way but can get stuck in your stomach due to non-responding valves.
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Metformin is the drug that doctors are supposed to prescribe first according to the American Diabetes Association's standard practice recommendations and those of the Amercian Association of Clinical Endocrinologists, but many family doctors are swayed by drug salespeople's hype.
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These new criteria will significantly increase the prevalence of GDM, primarily because only one abnormal value, not two, is sufficient to make the diagnosis.
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