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Effect of intial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes.
Given that this arm of the study depends on comparison of two open treatment regimens, albeit randomised, the progressive awareness of the importance of 'tight glucose control' across the world will make it harder to achieve this separation.
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With accumulating data establishing the glycemic control and other benefits of the incretin agents, it is now possible to envision how these new drugs might eventually be incorporated into routine care of T2DM.
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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
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What you need to ask is what is the “mechanism” in this diet that causes that?
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Evidence-based diabetes care could be highly cost effective.
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Primary endpoint was a 25% greater reduction in urinary protein excretion (detected using 24-hour urine determinations) in the combination group as compared to either trandolapril or verapamil alone.
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While actual health outcomes were not evaluated in this study, overall it provides strong support for the results of most prospective epidemiologic studies that show lower rates of cardiovascular and other diseases among light-to-moderate drinkers than among abstainers or heavy drinkers.
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